:root{
  --bg:#ffffff; --fg:#1a1d21; --muted:#5b6570; --line:#e3e7ec; --soft:#f6f8fa;
  --accent:#1a5d8f; --accent-soft:#e8f1f8; --warn:#8a5a00; --warn-soft:#fdf4e3;
  --good:#1d6f42; --bad:#9a2c2c;
}
*{box-sizing:border-box}
body{margin:0;background:var(--bg);color:var(--fg);
  font:16px/1.62 -apple-system,BlinkMacSystemFont,"Segoe UI",Helvetica,Arial,sans-serif;
  -webkit-text-size-adjust:100%}
.wrap{max-width:980px;margin:0 auto;padding:0 20px}
header.site{border-bottom:1px solid var(--line);background:var(--bg);position:sticky;top:0;z-index:20}
header.site .wrap{display:flex;align-items:center;gap:22px;flex-wrap:wrap;padding-block:14px}
.brand{font-weight:650;letter-spacing:-.01em;color:var(--fg);text-decoration:none;font-size:17px}
nav.site{display:flex;gap:18px;flex-wrap:wrap;margin-left:auto}
nav.site a{color:var(--muted);text-decoration:none;font-size:15px}
nav.site a:hover,nav.site a.on{color:var(--accent)}
h1{font-size:31px;line-height:1.22;letter-spacing:-.02em;margin:34px 0 10px}
h2{font-size:22px;letter-spacing:-.01em;margin:38px 0 10px;padding-top:6px}
h3{font-size:17px;margin:26px 0 8px}
p{margin:0 0 14px}
.lede{font-size:18px;color:#333a42}
a{color:var(--accent)}
.muted{color:var(--muted)}
.small{font-size:14px}
code{font:13px/1.5 ui-monospace,SFMono-Regular,Menlo,monospace;background:var(--soft);
  padding:1px 5px;border-radius:4px}
.tablewrap{overflow-x:auto;margin:14px 0}
table{border-collapse:collapse;width:100%;font-size:15px;min-width:460px}
th,td{border-bottom:1px solid var(--line);padding:8px 12px;text-align:left;vertical-align:top}
th{font-weight:600;color:var(--muted);font-size:13px;text-transform:uppercase;letter-spacing:.04em}
td.num,th.num{text-align:right;font-variant-numeric:tabular-nums}
tr.pick td{background:var(--accent-soft)}
.note{background:var(--soft);border:1px solid var(--line);border-left:3px solid var(--accent);
  border-radius:6px;padding:14px 16px;margin:18px 0}
.note.warn{border-left-color:var(--warn);background:var(--warn-soft)}
.note p:last-child{margin-bottom:0}
.cards{display:grid;grid-template-columns:repeat(auto-fit,minmax(240px,1fr));gap:14px;margin:18px 0}
.card{border:1px solid var(--line);border-radius:8px;padding:16px;background:var(--bg)}
.card h4{margin:0 0 6px;font-size:16px}
.card p{margin:0;font-size:14.5px;color:var(--muted)}
.card .big{font-size:26px;font-weight:650;color:var(--fg);font-variant-numeric:tabular-nums;
  letter-spacing:-.02em;display:block;margin-bottom:2px}
.btn{display:inline-block;background:var(--accent);color:#fff;border:0;border-radius:6px;
  padding:10px 18px;font-size:15px;font-weight:550;cursor:pointer;text-decoration:none}
.btn:hover{background:#14486e}
.btn[disabled]{background:#9aa5b1;cursor:not-allowed}
.btn.sec{background:var(--bg);color:var(--accent);border:1px solid var(--line)}
label{display:block;font-weight:600;font-size:14px;margin:14px 0 5px}
select,input[type=text],textarea{width:100%;padding:9px 11px;border:1px solid var(--line);
  border-radius:6px;font:15px/1.4 inherit;background:var(--bg);color:var(--fg);min-width:0}
textarea{font-family:ui-monospace,SFMono-Regular,Menlo,monospace;font-size:13.5px}
.step{border-top:1px solid var(--line);padding-top:20px;margin-top:26px}
.step .n{font-size:12px;font-weight:700;color:var(--accent);letter-spacing:.09em;text-transform:uppercase}
footer.site{border-top:1px solid var(--line);margin-top:52px;padding:26px 0 44px;
  color:var(--muted);font-size:14px}
.pill{display:inline-block;font-size:12px;font-weight:650;padding:2px 9px;border-radius:999px;
  background:var(--soft);color:var(--muted);border:1px solid var(--line)}
.pill.ok{background:#e8f5ee;color:var(--good);border-color:#c5e5d3}
.pill.no{background:#fdecec;color:var(--bad);border-color:#f3cfcf}
.bar{height:7px;border-radius:4px;background:var(--soft);overflow:hidden;min-width:70px}
.bar>span{display:block;height:100%;background:var(--accent)}
@media(max-width:760px){
  h1{font-size:26px}
  header.site .wrap{gap:12px}
  nav.site{margin-left:0;width:100%;gap:14px}
}

figure.arch{margin:22px 0 26px;border:1px solid var(--line);border-radius:9px;
  padding:10px 10px 4px;background:var(--bg)}
figure.arch img{display:block;width:100%;height:auto}
figure.arch figcaption{font-size:13.5px;color:var(--muted);padding:8px 6px 10px;line-height:1.5}

figure.arch figcaption .smi{margin-top:12px;padding-top:12px;border-top:1px solid var(--line);
  display:grid;gap:10px}
figure.arch figcaption .smi code{display:inline-block;margin-top:3px;font-size:12.5px;
  line-height:1.45;word-break:break-all;white-space:normal;background:var(--soft);
  padding:5px 8px;border-radius:5px;color:var(--fg);user-select:all}

/* ---- Ketcher panes ----------------------------------------------------
   Editors are stacked full width, never side by side: Ketcher's top toolbar
   does not fit in a half-width column and silently truncates, hiding exactly
   the controls people reach for. Learned on the kinase site. */
.ketcher-box{border:1px solid var(--line);border-radius:8px;overflow:hidden;background:var(--bg)}
.ketcher-box iframe{display:block;width:100%;height:460px;border:0}
@media(max-width:760px){ .ketcher-box iframe{height:380px} }
.smiles-out{font:12.5px/1.5 ui-monospace,SFMono-Regular,Menlo,monospace;
  word-break:break-all;color:var(--fg)}
.gate{border:1px solid var(--line);border-left:3px solid var(--accent);border-radius:8px;
  padding:14px 16px;background:var(--soft);margin:18px 0}
.gate-title{font-weight:650;font-size:15px;display:block;margin-bottom:4px}
.gate-sub,.gate-fine{font-size:13.5px;color:var(--muted);margin:0 0 8px}
.gate-fine{margin:8px 0 0}
.gate-unlock{font-size:13px;color:var(--accent);font-weight:600;margin:8px 0 0}
.gate input{max-width:360px}
[data-needs-email][disabled]{opacity:.5;cursor:not-allowed;background:var(--soft)}
.hint{font-size:13.5px;color:var(--muted);margin:4px 0 8px}

nav.sister{margin-top:16px;display:grid;grid-template-columns:auto 1fr;gap:4px 14px;
  align-items:baseline;font-size:14px}
nav.sister b{grid-column:1/-1;color:var(--fg);font-size:13px;text-transform:uppercase;
  letter-spacing:.04em;margin-bottom:2px}
nav.sister a{white-space:nowrap;font-weight:550}
@media(max-width:600px){ nav.sister{grid-template-columns:1fr;gap:2px}
  nav.sister span{margin-bottom:8px} }